Saar Biotech

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Description

Levocetirizine Dihydrochloride Syrup :
Levocetirizine is an antihistamine which is used to treat various kinds of allergies. An allergy is an immune system response to foreign elements typically not harmful to the body. These foreign elements are known as 'allergens.' Allergic conditions vary from person to person. Some might be allergic to certain foods and seasonal allergies like hay fever. At the same time, others might be allergic to pollen or pet dander. Levocetirizine Hcl is used to treat symptoms of perennial allergies in adults and children who are at least 6 months old. Levocetirizine Hcl is also used to treat symptoms of seasonal allergies in adults and children who are at least 2 years old and it is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old.

Indications

Allergic Rhinitis: It is an allergic reaction that causes sneezing, congestion, itchy nose and watery eyes. Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.
Chronic Idiopathic Urticaria: Levocetirizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria (red, itchy skin welts) in adults and children 6 years of age and older.
Pruritus: Levocetirizine syrup provides relief from pruritus, which is characterized by intense itching caused by conditions like eczema, allergic reactions, and insect bites.

Pharmacokinetics

Absorption: Rapidly and extensively absorbed. T max is 0.9 h. C max is 270 and 308 ng/mL after single and repeated once-daily dosing, respectively. Steady state achieved after 2 days.
Distribution: Plasma protein binding about 92%. Vd is approximately 0.4 L/kg.
Metabolism: Metabolism is less than 14% and by aromatic oxidation, N- and O'Dealkylation, and taurine conjugation.
Elimination: The t ½ is about 8 to 9 h. Elimination is 85.4% and 12.9% via urine and feces, respectively. Excreted both by glomerular filtration and active tubular transport.

Mechanism

Levocetirizine is the active enantiomer of cetirizine, which means it is a single isomer of the molecule that has more potent antihistamine activity and fewer side effects .It works by blocking the action of histamine, a chemical that is released by the body in response to an allergen. Histamine is responsible for many of the symptoms associated with allergies, such as itching, sneezing, runny nose, and hives.

Interactions

Levocetirizine Syrup have interactions with other antihistamines (such as diphenhydramine), antidepressants (such as duloxetine), pain killers (such as pregabalin), a medicine used to treat low blood pressure (such as midodrine), a medicine used to treat anxiety disorders and panic disorder (such as alprazolam) and anti-viral or anti-HIV drugs (such as ritonavir).

Contraindications

Patients with a known hypersensitivity to levocetirizine or any of the ingredients of levocetirizine dihydrochloride oral solution or to cetirizine Children 6 months to 11 years of age with renal impairment.

Side Effects

The most commonly reported adverse effects are:
• Drowsiness and fatigue
• Dizziness
• Dry Mouth
• Nausea and headache

Warning

"Response to medication may vary from one individual to another, containing side effects like (vertigo, dizziness, nervousness, insomnia) that have been reported very rarely."
To rule out any unpleasant side effects or interactions, inform your doctor about your child's health condition and the medications received. Do not give more than the stated recommended dose.

Storage

Store in a well closed container in a cool, dry place, away from direct heat and light.

Conclusion

From the above discussion, it can be concluded that this Levocetirizine dihydrochloride syrup could improve the symptoms of Allergic Rhinitis and Chronic Idiopathic Urticaria.