Halobetasol Propionate and Salicylic Acid ointment

Indications:- skin infection

OINTMENT PRESENTATION:
Each 5 ml contains:

Halobetasol Propionate USP 0.05% w/w
Salicylic acid IP 6% w/w

Description

This composition consists of two active ingredients i.e. Halobetasol propionate and salicylic acid which are used together to treat skin infections. They block the keratin clumps and soften the skin by removing the dead skin cells. Salicylic acid works by enhancing the absorption of Halobetasol in the skin.

LICENSED INDICATION

  • Psoriasis
  • Eczema
  • Corticosteroid responsive pruritis dermatoses
  • Warts
  • Acne
  • Wrinkles

Drug Interaction

Halobetasol propionate binds to the glucocorticoid receptors which mediated in the gene expression thus it inhibits phospholipase A2, neutrophil apoptosis therefore it decreases the formation of arachidonic derivatives that are responsible for inflammation and pain.
Salicylic acid helps to separate the dead cells from the living cells and prevents the clogging of pores or it promotes the growth of new cells.

Pharmacokinetics

Halobetasol propionate binds to the corticosteroid binding globulin in serum and excreted via urine.

Drug Interaction

  • Tretinoin
  • Adapalene
  • Metoprolol
  • Aspirin
  • Pregabalin

ADVERSE EFFECT

  • Burning
  • Itching
  • Redness
  • Thinning of skin

CONTRAINDICATION

  • Contraindicated in patients with known hypersensitivity
  • Contraindicated in diabetes mellitus
  • Contraindicated in pregnancy

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