Ambroxol + Dextromethorphan + Phenylephrine + CPM + Menthol Syrup

Ambroxol + Dextromethorphan + Phenylephrine + CPM + Menthol Syrup belongs to the Syrups category within the Cough & Cold and Respiratory therapeutic segments. This five-molecule formulation addresses the complete clinical picture of cough and cold:

• Ambroxol 15mg — a mucolytic that thins and loosens phlegm
• Dextromethorphan 10mg — a centrally acting antitussive that suppresses dry cough
• Phenylephrine 5mg — a nasal decongestant that relieves blocked nose
• Chlorpheniramine Maleate 2mg — an antihistamine that relieves allergic symptoms
• Menthol 1.5mg — a soothing agent that provides cooling relief

For pharmaceutical marketing companies, this is a seasonally robust respiratory SKU with high prescription volume during monsoon and winter. Saar Biotech manufactures it from our facility in Baddi with validated five-API syrup quality control and complete 60ml and 100ml packaging options.

At Saar Biotech, we manufacture this five-component syrup using a controlled oral syrup manufacturing process that ensures dose uniformity, flavour acceptance, and packaging reliability.

• Five-API Homogenization: Each of the five active ingredients must be uniformly distributed in the syrup vehicle. Our high-shear mixing and validated fill procedures ensure dose-to-dose consistency.

• Taste Masking: Multiple active ingredients with bitter profiles require expert taste masking. We develop Mixed Fruit and Strawberry-flavoured syrup bases that mask the bitterness of Dextromethorphan and Ambroxol.

• pH and Stability Management: All five actives must remain chemically stable for 24 months under tropical storage conditions. Our formulation team selects preservatives, pH buffers, and solubilizers that protect all actives from degradation.

• 60ml and 100ml Pack Coverage: From dark amber bottles to measuring caps and printed caps — Saar Biotech’s packaging options help cough syrup brands stand out.

This syrup is manufactured and supplied by Saar Biotech for the following established clinical indications:

• Productive Cough with Bronchospasm: Ambroxol addresses mucus clearance while Dextromethorphan suppresses dry cough

• Nasal Congestion: Phenylephrine provides effective nasal decongestion

• Allergic Cold Symptoms: CPM relieves runny nose, watery eyes, and sneezing

• Upper Respiratory Irritation: Menthol provides soothing relief

Five-Component Clinical Mechanism

Ambroxol is a mucolytic agent that thins and loosens phlegm in the lungs, windpipe, and nose.

Dextromethorphan is a centrally acting antitussive that suppresses the cough reflex.

Phenylephrine is a nasal decongestant that narrows blood vessels in the nasal passages.

Chlorpheniramine Maleate is an antihistamine that blocks histamine receptors, reducing allergic symptoms.

Menthol provides a soothing, cooling effect on the respiratory tract.

Manufacturing Integrity

• Five-API Compatibility: Each active must remain chemically stable in the shared syrup vehicle.
• Menthol Solubilization: Menthol’s crystalline nature requires complete dissolution in a compatible co-solvent.

Saar Biotech provides Third-Party Manufacturing and Contract Manufacturing for this syrup from our dedicated oral liquid manufacturing facility in Baddi, Himachal Pradesh.

• Facility: Oral liquid manufacturing area with controlled processing, automated bottle filling, capping, labelling, and carton packing lines.
• Capacity: Scalable from brand-entry launches to large seasonal batches.
• Quality Lab: In-house GLP-certified lab with validated HPLC assay for all five actives.
• Turnaround: New orders — 30 to 45 working days. Repeat orders — 20 to 25 working days.
• Packaging: 60ml and 100ml PET or dark amber bottles; sticker label, metallic label, measuring cup, printed cap.
• MOQ: Starting at 5,000–10,000 units per SKU.

1. Warehouse Conditions: Store below 30°C in a cool, dry environment.
2. Light Protection: Keep bottles away from direct sunlight.
3. Measuring Cap Use: A calibrated measuring cap ensures accurate dosing.
4. Post-Opening: Tightly close the cap after each use.

Every commercial batch is quarantined until it passes a comprehensive analytical release protocol:

• Five-API HPLC Assay: Simultaneous quantification of all five actives against IP specifications.
• pH & Viscosity Testing: The syrup’s pH and flow characteristics are monitored.
• Microbial Limit Testing (MLT): IP-compliant microbiological testing.
• Certificate of Analysis (COA): Issued with every B2B batch.

• CNS Depression (CPM): Chlorpheniramine produces sedation and somnolence.
• Serotonin Syndrome Risk (Dextromethorphan): Contraindicated with MAO inhibitors.
• Cardiovascular Caution (Phenylephrine): Use with caution in patients with hypertension.
• Contraindications: Hypersensitivity to any component. Use with caution in patients with hepatic or renal impairment.

For third-party manufacturing enquiries, private-label contracts, or to request pricing and packaging options for Ambroxol + Dextromethorphan + Phenylephrine + CPM + Menthol Syrup, please use the B2B enquiry form below.