Clindamycin + Nicotinamide Gel

Clindamycin + Nicotinamide Gel belongs to the Gels category and is classified as a topical antibiotic and anti-inflammatory preparation.

• Clindamycin Phosphate 1% — antibiotic that inhibits bacterial protein synthesis, reducing P. acnes growth
• Nicotinamide 4% — anti-inflammatory agent that reduces redness and inflammation

Saar Biotech manufactures DCGI-approved formulations of this combination gel from our manufacturing facility in Baddi, available in 10gm, 15gm, 20gm, and 30gm laminated tube formats.

At Saar Biotech, we manufacture Clindamycin + Nicotinamide Gel using a precision-controlled homogenization process that ensures every tube delivers uniform API distribution, consistent sensory performance, and stable shelf-life potency.

• Two-API Uniformity: Homogeneous dispersion of both actives is achieved through validated mixing sequence.
• Viscosity Consistency: Every batch is tested for viscosity to ensure the gel spreads easily and maintains correct texture.
• pH-Optimised Base: The gel base is formulated and verified within a skin-compatible pH range.
• Tube Filling Precision: Automated laminated tube filling lines ensure accurate fill weight per tube.

Clindamycin + Nicotinamide Gel is manufactured by Saar Biotech for the following clinically recognised indications:

• Acne Vulgaris: Treatment of inflammatory acne lesions
• Acne Management: Effective for mild to moderate acne
• Inflammatory Skin Conditions: Reduction of redness and inflammation

Clindamycin Phosphate is a lincosamide antibiotic that binds to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis and reducing Propionibacterium acnes growth. Nicotinamide reduces inflammation by inhibiting cytokine release and decreasing neutrophil chemotaxis.

Manufacturing Integrity

• Chemical Stability: Both actives remain chemically stable in the gel base.
• Preservation System: The gel includes a validated preservation system.

Saar Biotech offers specialised Contract Manufacturing (CMO) and Third-Party Manufacturing services for Clindamycin + Nicotinamide Gel from our semi-solid manufacturing facility in Baddi, Himachal Pradesh.

• Facility: Dedicated semi-solid manufacturing lines with planetary mixer homogenizers and automated laminated tube filling and sealing equipment.
• Capacity: Pilot batches from 5,000 tubes to commercial runs of 1,00,000+ tubes.
• Quality Lab: GLP-certified in-house QC with HPLC, pH metres, viscometers, and stability chambers.
• Turnaround: 30–45 working days for new orders; 20–25 working days for established repeat partners.
• Packaging: 10gm, 15gm, 20gm, and 30gm laminated aluminium tubes with custom mono-carton and label design.
• Regulatory: DCGI-compliant; full COA, batch records, and stability data provided.
• MOQ: 5,000–10,000 tubes per SKU.

1. Sealed Tube Storage: Store below 30°C in a cool, dry location away from direct sunlight and heat sources. Do not freeze.
2. In-Use Handling: Replace the cap firmly after each use.
3. Application Precautions: Apply exclusively to intact skin. Keep away from eyes, mucous membranes, and broken skin.

Every batch is released only after completing the following analytical protocol:

• HPLC Assay (Two-API): Individual assay of Clindamycin Phosphate and Nicotinamide.
• pH Testing: Verification of pH within skin-compatible specification range.
• Viscosity Testing: Measurement of gel viscosity confirming batch-to-batch consistency.
• Microbial Limit Test (MLT): Confirms total aerobic count and absence of specified pathogens.
• Certificate of Analysis (COA): Issued with every B2B consignment.

Common Side Effects: Local irritation, redness, dryness, peeling, and burning sensation.

Contraindications: Known hypersensitivity to any component. Not for use on broken skin, open wounds, or mucous membranes.

Precautions: Avoid contact with eyes. Use during pregnancy and lactation only under physician supervision.

For B2B manufacturing enquiries, third-party contracts, or to request complete product details for Clindamycin + Nicotinamide Gel, please use the enquiry form below.