Paracetamol + Promethazine Syrup

Paracetamol + Promethazine Syrup belongs to the Syrups category within the Cough & Cold and Anti-Histamines therapeutic segments. This combination addresses both fever/pain and allergic symptoms in a single formulation.

• Paracetamol 125mg — analgesic and antipyretic for fever and body ache
• Promethazine Hydrochloride 5mg — sedating antihistamine for allergic symptoms

For pharmaceutical marketing companies, this is a high-prescription cold-care product with consistent demand. Saar Biotech manufactures it from our manufacturing facility in Baddi.

At Saar Biotech, we manufacture this syrup using a controlled oral syrup manufacturing process that ensures dose uniformity, palatability, and packaging reliability.

• Two-API Uniformity: Both actives are uniformly distributed for consistent dosing.
• Taste Masking: Both APIs have bitter profiles requiring expert taste-masking.
• pH and Stability Management: Both actives remain chemically stable for 24 months.
• 60ml Pack Coverage: From dark amber bottles to drip-off embossed cartons.

This syrup is manufactured and supplied by Saar Biotech for the following established clinical indications:

• Common Cold & Fever: Symptomatic relief of fever, body ache, and malaise
• Allergic Rhinitis: Relief from runny nose, sneezing, and allergic symptoms
• Upper Respiratory Infections: Symptomatic management of cold and flu symptoms

Schedule H — Requires valid medical prescription. Not for use in children under 2 years.

Paracetamol inhibits prostaglandin synthesis in the hypothalamic thermoregulatory centre, reducing fever and raising the pain threshold. Promethazine is a first-generation antihistamine that blocks H1 receptors, reducing histamine-mediated rhinorrhea, sneezing, and allergic symptoms.

Manufacturing Integrity

• Two-API Compatibility: Both actives remain chemically stable in the shared syrup vehicle.
• pH Stability: The syrup base is pH-buffered to maintain both actives’ chemical integrity.

Saar Biotech provides Third-Party Manufacturing and Contract Manufacturing for this syrup from our dedicated oral liquid manufacturing facility in Baddi, Himachal Pradesh.

• Facility: Oral liquid manufacturing area with controlled processing, automated bottle filling, capping, labelling, and carton packing lines.
• Capacity: Scalable from brand-entry launches to large commercial batches.
• Quality Lab: In-house GLP-certified lab with validated HPLC assay for both actives.
• Turnaround: New orders — 30 to 45 working days. Repeat orders — 20 to 25 working days.
• Packaging: 60ml PET or dark amber bottles; sticker label, metallic label, measuring cup, printed cap.
• MOQ: Starting at 5,000–10,000 units per SKU.

1. Warehouse Conditions: Store below 30°C in a cool, dry environment.
2. Light Protection: Keep bottles away from direct sunlight.
3. Measuring Cap Use: A calibrated measuring cap ensures accurate dosing.

Every commercial batch is quarantined until it passes a comprehensive analytical release protocol:

• Two-API HPLC Assay: Simultaneous quantification of Paracetamol and Promethazine.
• pH & Viscosity Testing: The syrup’s pH and flow characteristics are monitored.
• Microbial Limit Testing (MLT): IP-compliant microbiological testing.
• Certificate of Analysis (COA): Issued with every B2B batch.

• Sedation (Promethazine): Causes significant drowsiness; avoid driving and alcohol.
• Contraindications: Hypersensitivity to any component; epilepsy, glaucoma, prostatic hypertrophy; children under 2 years.
• Drug Interactions: Potentiates CNS depressants, alcohol, and sedatives.

For third-party manufacturing enquiries, private-label contracts, or to request pricing and packaging options for Paracetamol + Promethazine Syrup, please use the B2B enquiry form below.