Promethazine Hydrochloride

SUSPENSION PRESENTATION:
Each 5 ml contains:
Promethazine Hydrochloride IP 5 mg

Promethazine HCL Suspension:
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Features of Oral Solution

• Accurate composition
• Quick results
• Less side effect
• Purity

What is Promethazine HCl Oral Solution?
Promethazine is an antihistamine which can be taken by mouth as an oral solution whose uses are as following:-

• "Hay fever," or, a stuffy runny nose from allergy.
• Watery, itchy eyes due to inhaled allergies and foods.
• Mild allergic skin reactions with itching and swelling.
• Allergic reactions to blood or plasma.
• dermographism, a form of hives known as "skin writing".
• Serious allergic reactions along with epinephrine and other treatments.
• Sedation before or after surgery, or during childbirth.
• Prevention and control of nausea and vomiting after surgery.
• Along with meperidine (demerol) or other pain medicines.
• Sedation, relief of anxiety, and production of light sleep from which the patient can be easily aroused.
• Treatment and prevention of motion sickness.

• Absorption: On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
• Protein binding: 93%
• Metabolism:Promethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites.
• Route of elimination: Urinary tract
• Half life: 16-19 hours

Promethazine interacts with the following class of drugs, therefore severe caution must be exercised while co-administering these drugs with promethazine Oral Solution as it may prove to be fatal at some level :-

• CNS Depressants
• Epinephrine
• Anticholinergics
• Monoamine Oxidase Inhibitors (MAOI).

• Headache/Dizziness
• Dry mouth
• Loss of appetite

• Tiredness
• Blurred vision

• Promethazine HCl Oral Solution is contraindicated for use in pediatric patients less than two years of age.
• Promethazine HCl Oral Solution is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
• Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma.

• Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.
• Promethazine HCl Oral Solution should be used cautiously in persons with cardiovascular disease or with impairment of liver function.