DESCRIPTION

This drops of vitamin D3 helps to get rid of bone disorders such as rickets and osteomalacia in children. As, the age and dark skin leads to restricted exposure to sunlight thus this result in deficiency of vitamin D.

Indications

• It helps in the metabolism of calcium and phosphorus
• It helps to build strong bones and teeth’s
• It promotes the growth and development of kids
• It enhances the function of immune system

Mechanism

Vitamin D acts on the receptors present in the small intestine which enhances the absorption of calcium and phosphorus. It also stimulates the receptors present in osteoblasts which stimulates the nuclear factor KB which helps the maturation of bones for reabsorption of calcium and phosphorus.

Pharmacokinetics

• Absorption- It is absorbed orally from the small intestine
• Protein Binding- It is 50-80% bound to proteins
• Metabolism- It undergoes hydroxylation and converted into 25-hydroxycalciderol
• Excretion- It is excreted via bile and feces

Interactions

• Phenobarbital
• Phenytoin
• Atorvastatin

Side Effects

• ✓
  Nausea
• ✓
  Vomiting
• ✓
  Poor appetite
• ✓
  Stomach-ache
• ✓
  Constipation
• ✓
  Diarrhoea

Contraindication

• Contraindicated in sarcoidosis
• Contraindicated in Kidney stones
• Contraindicated in kidney disease